At a Glance


  • STEM
  • Chemistry

Instructional Level

  • College & CEGEP
  • University


  • Organic Chemistry

Tasks in Workflow

Social Plane(s)

  • Individual
  • Group

Type of Tasks

  • Solving problems
  • Taking a quiz & test

Technical Details

Class size

  • Small (20-49)


  • Single class period (< 90 mins)

Instructional Purpose

  • Assessment & knowledge refinement


The aim of this activity is to test the students’ understanding of the relationships between different stereoisomers and their 3D visualization skills of organic molecules using a two-stage test.

Just before class, the instructor sets up the activity in a laboratory space.

One set of 3 different stations are set up around the classroom (setup A), while another set of 3 stations, that are slightly different, are also setup around the classroom (setup B).

The stations from setup A are interspersed with the stations from setup B, with maximum spacing in between the stations. This is to ensure that during class time, groups working on the same set of stations cannot hear each other’s answers.

The stations are covered (they are only revealed at the start of Part 2 of the two-stage test).

During the lecture time, students complete a Two-stage test.

Part 1: A written 20 minute individual assessment containing stereochemistry questions. Students submit their answers at the end of Part 1.

Part 2: Students form groups of 3 to 4 and participate in a group assessment for the next 30 minutes. Half of the groups visit setup A and the other half visit setup B. Groups visit each station (for 10 minutes each) and answer the corresponding questions. Each group submits their answers at the end of Part 2 once they have visited all the stations.

All the questions to be answered for Part 2 are provided on a sheet of paper which each group is given. The stations are as follows:

Station 1: A bond-line drawing of a complex organic molecule. Students are asked to identify whether the designated carbons are chiral (up to 12) and determine the configuration of each stereocenter (R or S).

Station 2: Three different displays all containing: 1 molecular model and 1 pair of molecular drawings (either Newman projection, Fischer projection or bond-line structure), ideally all encased in a transparent plastic box. For each display, students are asked to identify the relationship between the pair of drawings (enantiomers, diastereomers, or constitutional isomers) and which drawing represents the 3D  model without touching the model.


Station 3: A molecular model of a long carbon chain with various substituents. Students are asked to draw a Fischer projection of the model starting with a particular group on top and ending with a particular group on the bottom, without touching the model.

For the two stage test, there is a flexible grading scheme: either 85% individual and 15% group or 100% individual; whichever is the highest.

After class, the instructor will post solutions online, including pictures of all the 3D models. Each picture will be matched up with the corresponding molecular drawing.

Instructional Objectives

  • To improve 3D visualization skills for organic molecules;
  • To identify relationships between stereoisomers;
  • To apply different molecular 3D drawing techniques (Newman projection, Fischer projection and bnd-line structure).

Contributor's Notes

Carmen Leung

Carmen Leung

Dawson College, Montreal, QC

  • Students collaborate and learn from each other on how to interpret molecules in 3D based on molecular drawings (Newman projection, Fischer projection and bond-line structure);
  • Students who participated in this activity generally did well in the assessment.
  • The instructor is not sure whether quieter or weaker students get as much input as other students (they may perhaps still benefit from the group discussions).
  • For the Fischer projection drawing, indicate which end of the molecular model is the top end; this makes grading much easier;
  • Ensure there are enough stations so that every group is at a station with one group per station;
  • The molecular models should be arranged differently from the molecular drawings to provide more challenge to the 3D visualization of the molecules.

Applied Strategies


Leave a comment! Activities get better when we receive feedback and understand how they might be adapted and reused. Please let us know what you think after using this Activity, or if you have questions about how it might be used differently.

Your email address will not be published. Required fields are marked *