Overview

Gene mutations can be lethal or beneficial to an organism, in this mini case study students will learn the effects mutations can have on phenotypes.

Students will apply what they learned about mutations to decipher the effects it can have on a functional gene (phenotype). They will investigate the outcomes of two mutations; one that leads to a truncated null protein product and one that leads to a functional larger protein.
This mini case study uses the flipped classroom strategy where students will prepare by watching videos, completing assigned readings and taking a quiz before entering the classroom. The instructor ...

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Gene mutations can be lethal or beneficial to an organism, in this mini case study students will learn the effects mutations can have on phenotypes.

Students will apply what they learned about mutations to decipher the effects it can have on a functional gene (phenotype). They will investigate the outcomes of two mutations; one that leads to a truncated null protein product and one that leads to a functional larger protein.
This mini case study uses the flipped classroom strategy where students will prepare by watching videos, completing assigned readings and taking a quiz before entering the classroom. The instructor can use just in time teaching (JITT) using the quiz results to alter the in-class material.

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Objectives

  • To understand the effects that a mutation can have, whether it can be lethal or beneficial;
  • To understand what the mutation can do to an organism’s phenotype.

Context and requirements

Level College
Discipline Biology
Course General Biology II
Activity Content Youtube videos, assigned readings, in-class activity, clicker questions (ppt) and key concepts/learning outcomes
Technological Requirements Clicker/Clicker pads
Best Use Mini case study

Author’s Notes

Benefits

  • This activity helps students in group collaboration. Since the activity uses peer assessment the student’s are more engaged.

Challenges

  • Students get overwhelmed when faced with the multiple choice clicker questions.

Tips

  • This case study is applicable to any gene; therefore the instructor can modify the study to the gene/sequence of their choice;
  • The instructor can use the clicker questions at the beginning of the class.

Activity Pedagogical Components

CASE STUDY

For a description of this strategy, please see here.

PEER INSTRUCTION

For a description of this strategy, please see here.

PEER ASSESSMENT

For a description of this strategy, please see here.

FLIPPED CLASSROOM

For a description of this strategy, please see here.

JUST IN TIME TEACHING (JITT)

For a description of this strategy, please see here.

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